Arsenal boss Mikel Arteta has just two fit recognised central defenders available for the Europa League Group B visit of Dundalk.
Shkodran Mustafi and Gabriel Magalhaes are his only options, with David Luiz (thigh) joining Rob Holding (hamstring), Pablo Mari (ankle) and Calum Chambers (knee) on the sidelines.
The Irish underdogs came close to a surprise win in their Group B opener versus Molde, taking the lead early on before going down 2-1 at home.
Fellow defenders Sokratis Papastathopoulos and William Saliba are unavailable having been left out of the Europa League squad but Willian is in contention having recovered from a slight ankle knock which sidelined him at the weekend, with Bukayo Saka also available despite limping off against Leicester.
It was the reverse storyline for the Gunners, who trailed 1-0 at Rapid Vienna with just 20 minutes left before goals from David Luiz and Pierre-Emerick Aubameyang ensured they took the points home.
Arsenal vs Dundalk Team News
David Luiz, Pablo Mari, Rob Holding and Gariel Martinelli are all injured for Arsenal, while Willian is also doubtful.
Dane Massey is still recovering from a hip injury, while Nathan Oduwa will be assessed after a spell on the sidelines.
Midfielder Reiss Nelson will be keen to be involved, with Arteta revealing the club looked to loan him out during the summer, only for the forward to insist he wanted to stay and fight for his place.
Arsenal host League of Ireland Premier Division side Dundalk in the second round of Europa League group stage fixtures on Thursday night.
The Gunners enter the Group B encounter off the back of a disappointing defeat at the hands of Premier League rivals Leicester City over the weekend, but their opponents suffered a similar fate to domestic rivals Waterford last time out.
Despite hearing several plaudits since his arrival, Mikel Arteta has seen his side’s form suffer of late and will view this midweek clash as the perfect opportunity to get back on track.